Timothy C. Humphrey

This study shows that the transcription factor MITF interacts with the MRN complex to modulate the DNA damage response in melanoma, contributing to cancer predisposition.

The paper measures mutation rates in S. pombe using canavanine resistance and finds that spontaneous mutants predominantly have an R175C mutation in the any1 gene, which confers resistance through altered arginine transport and cell morphology.

The paper identifies a switch from DICER-dependent to Argonaute-mediated miRNA biogenesis in cancer, showing that non-canonical processing of oncogenic miRNAs promotes cancer progression.

The paper shows that inherited broken chromosomes in S. pombe undergo cycles of replication and processing, leading to chromosomal instability and rearrangements.

The paper shows that disrupting dNTP homeostasis is synthetically lethal with CDK-induced replication stress in fission yeast, leading to genome instability and cell death.