Dave Maurice De Sousa

This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.

This study shows NR4A3 is not required for generating CD8+ resident memory T cells in epithelial or non-epithelial sites, unlike NR4A1 and NR4A2.