Patrizia Caposio

This study shows that HCMV miRNAs miR-US5-2 and miR-US25-2 downregulate Dvl3 during latency to enable efficient reactivation in CD34+ HPCs.

This paper shows that HCMV's UL22A protein is essential for reactivation from latency in CD34+ hematopoietic progenitor cells, with tyrosine residues critical for this process, but RANTES neutralization does not fully restore reactivation.

This study shows HCMV uses UL8 and miR-UL36 to suppress Notch signaling, promoting reactivation in CD34+ hematopoietic progenitor cells.

This study identifies UL78 as a nuclear-localized GPCR essential for HCMV reactivation from latency in CD34+ HPCs, showing its Gi coupling and interactome involvement in nuclear processes.

The paper analyzes the transcriptional network of HCMV in latency by comparing gene expression with and without UL135 and UL138, revealing their roles in viral gene regulation and hematopoietic differentiation.

This study shows that HCMV miRNAs downregulate Akt to promote reactivation from latency in CD34+ cells and humanized mice.