The human cytomegalovirus chemokine binding protein UL22A is necessary for efficient reactivation from latency in CD34+ hematopoietic progenitor cells.
Rebekah Turner, Nicole L. Diggins, Luke Slind, Jennifer Mitchell, Andrew H. Pham, Christopher J. Parkins, Wilma D. Perez, Samuel Medica, Michael C. Denton, Takeshi F. Andoh, Gabriela M. Webb, Daniel Andrade-Vera, Daniel N. Streblow, Patrizia Caposio, Meaghan H. Hancock
This paper shows that HCMV's UL22A protein is essential for reactivation from latency in CD34+ hematopoietic progenitor cells, with tyrosine residues critical for this process, but RANTES neutralization does not fully restore reactivation.
Journal of Virology · Jul 27, 2026Peer-reviewedMicrobiology