Author

Mudita Pincha

F. Hoffmann-La Roche AG

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Christian KleiniD· 2 shared Maria AmanniD· 2 shared Ahmet VaroliD· 1 shared Alexander T. NguyeniD· 1 shared Ali Bransi· 1 shared Anthony J. SaviolaiD· 1 shared Aparna Neelakandhan· 1 shared Brooke NeupertiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Christian KleinORCID

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2 papers

Recent·Most cited

Chronic Antigen Stimulation in Solid Tumors Induces T Cell Exhaustion and Limits Efficacy of T Cell Bispecific Therapies

Idil Hutter-Karakoc, Eleni Maria Varypataki, Aparna Neelakandhan, Simone Lang, Vesna Kramar, Ahmet Varol, Sasha Simons, Marine Richard, Mudita Pincha, Dario Venetz, Nicole Joller, Christian Münz, Pablo Umaña, Christian Klein, Maria Amann

This study shows that chronic antigen exposure leads to T cell exhaustion, reducing the effectiveness of T cell bispecific therapies in solid tumors.

bioRxiv · Jan 29, 2025 · PreprintCancer Biology

Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment

Jacob Gadwa, Justin Yu, Miles Piper, Michael W. Knitz, Laurel B. Darragh, Nicholas A. Olimpo, Sophia Corbo, Jessica I. Beynor, Brooke Neupert, Alexander T. Nguyen, Chloe A. Hodgson, Diemmy Nguyen, Khalid N.M. Abdelazeem, Anthony J. Saviola, Laurène Pousse, , Sana D. Karam

This study shows that combining immunotherapies can lead to divergent tumor responses based on the tumor microenvironment, with Treg depletion reversing progression in pancreatic cancer.

Journal for ImmunoTherapy of Cancer · Jan 1, 2025Peer-reviewedImmunology