Filipa Costa Simões

The paper maps cardiac-immune microniches in regenerating zebrafish hearts and identifies a fibroblast-macrophage interaction that promotes regenerative macrophage states.

The paper adapts the Ac/Ds transposition system to enable CRISPR/dCas9 interference for studying non-coding RNAs and enhancers in zebrafish without altering genetic sequences.

This study identifies Prrx1b's role in directing pro-regenerative fibroblasts during zebrafish heart regeneration, reducing fibrosis and promoting tissue repair.

The paper shows that sustained WT1 expression impairs cardiomyocyte maturation and leads to their transformation into epicardial cells in zebrafish.

The paper identifies distinct gene regulatory programmes in the zebrafish epicardium during development and regeneration, revealing differences from developmental programmes.

This study identifies three distinct epicardial subpopulations in developing zebrafish hearts using single-cell RNA-sequencing and reveals their unique functions in cell adhesion, migration, and leukocyte recruitment.