Michael C. Oldham

Coordinated dysregulation of modular gene activity in human neuropathologies

The paper introduces CoPA, a method to identify dysregulated gene coexpression modules in specific cell types across neuropathologies, finding reproducible dysregulation in Alzheimers and schizophrenia.

Cortical organoids reveal human-specific roles of METTL5 in neurodevelopment via regulation of CHCHD2

The paper investigates METTL5's role in human neurodevelopment using cortical organoids, finding it regulates CHCHD2 and affects neural progenitor proliferation.

Bulk and Mosaic Deletions of Egfr Reveal Regionally Defined Gliogenesis in the Developing Mouse Forebrain

This study investigates the role of EGFR in mouse forebrain development through bulk and mosaic deletions, revealing region-specific effects on glial lineage formation.

Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury

The paper identifies soluble TNF receptor 1 (sTNFR1) as a therapeutic target for spinal cord injury using multi-dimensional analysis of preclinical data.

Blood RNA Profiles are Diagnostic for Severity in Human Acute Spinal Cord Injury

The paper identifies 197 genes in peripheral blood cells whose expression correlates with acute spinal cord injury severity, achieving 72.7% accuracy in predicting injury grades.

Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes

The paper identifies core transcriptional features of human CNS cell classes by analyzing variation in intact tissue samples and shows species-specific differences in astrocyte biology.