Author

Rajiv R. Ratan

Cornell UniversityORCID 0000-0002-9081-2701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Adam R. FergusoniD· 1 shared Agnese RazzoliiD· 1 shared Allan YarahmadyiD· 1 shared Amity Lin· 1 shared Ana María CuervoiD· 1 shared Andy Cheuk‐Him NgiD· 1 shared Angela NguyeniD· 1 shared Arne HolmgreniD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Adam R. FergusonORCID

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3 papers

Recent·Most cited

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

Gillian Carling, Li Fan, Nessa R. Foxe, Kendra Norman, Man Ying Wong, Daphne Zhu, Carlo Corona, Agnese Razzoli, Fangmin Yu, Allan Yarahmady, Pearly Ye, Hao Chen, Yige Huang, Sadaf Amin, Rebecca Sereda, , Li Gan

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Neuron · Sep 30, 2024Peer-reviewedNeuroscience

Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury

John Russell Huie, Adam R. Ferguson, Nikos Kyritsis, Jonathan Z. Pan, Karen‐Amanda Irvine, Jessica L. Nielson, Patrick G. Schupp, Michael C. Oldham, John C. Gensel, Amity Lin, Mark Robert Segal, Rajiv R. Ratan, Jacqueline C. Bresnahan, Michael S. Beattie

The paper identifies soluble TNF receptor 1 (sTNFR1) as a therapeutic target for spinal cord injury using multi-dimensional analysis of preclinical data.

Scientific Reports · Feb 9, 2021Peer-reviewedNeuroscience

Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain

Daniel N. El Kodsi, Jacqueline M. Tokarew, Rajib Sengupta, Nathalie A. Lengacher, Andy Cheuk‐Him Ng, Heather Boston, Qiubo Jiang, Carina Palmberg, Chantal A. Pileggi, Bojan Shutinoski, Juan Li, Angela Nguyen, Travis K. Fehr, Doo Soon Im, Steve M. Callaghan, , Michael G. Schlossmacher

This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.

bioRxiv · Apr 26, 2020 · PreprintNeuroscience