Kevin W. Kelley

This study creates a human assembloid model of the ascending somatosensory pathway using pluripotent stem cells and demonstrates its functional connectivity and response to pain-related stimuli.

This study uses a morphogen screen in human neural organoids to generate diverse neural cell types and uncover design principles of brain region specification.

This paper integrates 36 single-cell transcriptomics datasets from human neural organoids into a unified atlas to assess cell type coverage and compare organoid protocols with primary brain tissue.

The paper develops an assembloid model of the human cortico-striatal-thalamic-cortical circuit to study its function and disease-related disruptions.

The paper uses CRISPR screens in human forebrain assembloids to identify NDD genes involved in interneuron generation and migration, revealing novel roles for the ER in migration.

The paper identifies core transcriptional features of human CNS cell classes by analyzing variation in intact tissue samples and shows species-specific differences in astrocyte biology.