Animal Behavior & CognitionbioRxivPreprint
Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex
Roberto Frau, Luca Concas, Giulia Braccagni…·Marco Bortolato
This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.