Author

Yangmeng Wang

GenentechORCID 0000-0002-7404-4896Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alejandro Martinez ChiblyiD· 2 shared Minyi ShiiD· 2 shared Yuxin LiangiD· 2 shared Aaron T. L. LuniD· 1 shared Adrian Waddell· 1 shared Aleksander ChlebowskiiD· 1 shared Antonina HafneriD· 1 shared Anwesha DeyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Alejandro Martinez ChiblyORCID

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2 papers

Recent·Most cited

Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells

Eun‐Jung Kim, Dexter X. Jin, Alejandro Martinez Chibly, Kristel M. Dorighi, Smruthy Sivakumar, Jack Kamm, Szymon Juszkiewicz, Kevin Cabrera, Rohit Reja, Yangmeng Wang, Rachel M. Nakagawa, Minyi Shi, Yuxin Liang, Anwesha Dey, Ethan S. Sokol, , Meng He

The paper identifies synthetic lethality between POLE exonuclease deficiency and high aneuploidy in cancer cells, suggesting POLE inhibition as a therapeutic strategy for aneuploid tumors.

Cancer Research · Jun 8, 2026Peer-reviewedCancer Biology

Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell state

Tomasz Włodarczyk, Aaron T. L. Lun, Diana H. Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, , Xiaosai Yao

Epiregulon infers single-cell TF activity using ATAC-seq and RNA-seq to predict drug response and identify drivers of cell state.

Nature Communications · Aug 2, 2025Peer-reviewedBioinformatics