Avery J. Lam

This study investigates how cell cycle dynamics influence T cell fate and exhaustion by analyzing single-cell data and manipulating cell cycle progression and signaling.

This study engineers CAR Tregs to secrete IL-10 via PDCD1-driven regulation, enhancing their suppressive function in vitro and in vivo.

The paper describes a germline variant in IKZF2 causing immune dysregulation, including AIHA and atopic dermatitis, and reports single-cell RNA sequencing findings on T cell dysfunction.