Joseph C. Holt

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

This study shows that systemic CGRP modulates inner ear potentials and induces migraine-like behaviors in mice, suggesting a direct role for CGRP in auditory and vestibular hypersensitivities.

The paper investigates how active outer hair cells drive cochlear fluid circulation using experimental and computational methods.

This study shows that Notch1 is critical for maintaining supporting cell identity in the vestibular organs, and its deletion leads to supporting cell conversion to hair cells and vestibular dysfunction.

This study shows that KCNQ2/3 channels are targeted by mAChR activation in mammalian vestibular afferents, modulating slow excitation and discharge rates.

This study identifies M3 mAChRs as mediators of efferent-mediated slow excitation in irregular vestibular afferents and suggests M1 mAChRs may drive similar effects in regular afferents.

This study shows outer hair cells can either amplify or suppress vibrations in the organ of Corti, affecting cochlear frequency tuning.