Persistence of vestibular function in the absence of glutamatergic transmission from hair cells
Mohona Mukhopadhyay, Ruchi Modgekar, Aizhen Yang-Hood, Kevin K. Ohlemiller, Valentin Militchin, Maolei Xiao, Zhijun Shen, Nicholas R. Rensing, Michael Wong, Suh Jin Lee, Rebecca P. Seal, Joseph C. Holt, Mark E. Warchol, Susan E. Maloney, Carla M. Yuede, , Tina Pangršič
This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.
Scientific Reports · Mar 23, 2026Peer-reviewedNeuroscience