Author

William Y. Kim

University of North Carolina at Chapel HillORCID 0000-0001-7922-2156Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alex M. JaegeriD· 1 shared Alina Cornelia IugaiD· 1 shared Andrew Leaver‐FayiD· 1 shared Arthi Hariharan· 1 shared Ashley B. MorrisoniD· 1 shared Ashley M. CliffiD· 1 shared Benjamin Garrett VincentiD· 1 shared Brian A. Belt· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

Alex M. JaegerORCID

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3 papers

Recent·Most cited

Immunodominance Hierarchy of Endogenous BBN963 Bladder Cancer Antigens Remains Stable Under Anti-PD1 and Anti-CTLA4 Immunotherapy

Misha Fini, Jessica Alley, Steven P. Vensko II, Dhuvarakesh Karthikeyan, Jin Seok Lee, Jason A. Garness, Emily Paul, Alex M. Jaeger, Nilu P Goonetilleke, William Y. Kim, Benjamin Garrett Vincent

This study identifies a stable immunodominance hierarchy of tumor antigens in a murine bladder cancer model under anti-PD1 and anti-CTLA4 therapy, suggesting broad antigen selection could improve immunotherapy.

bioRxiv · May 27, 2026 · PreprintCancer Biology

Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes

Xianlu Laura Peng, Ian C. McCabe, Elena V. Kharitonova, Yi Xu, Ryan T. Zhao, Changfei Luan, Joseph F. Kearney, Nancy Porterfield Kren, Arthi Hariharan, Jaewon James Lee, Justin Su, P. Chan, Ashley B. Morrison, Michelle E. LaBella, Silvia G. Hererra, , Jen Jen Yeh

The paper develops a classifier, DeCAF, to identify permissive and restraining cancer-associated fibroblast subtypes from bulk RNAseq data and validates its clinical relevance across multiple cancer types.

Cell Reports Medicine · Feb 1, 2026Peer-reviewedGenomics

Computational design of orthogonal TCR α/β interfaces for dual-TCR therapeutics

Tomoaki Kinjo, Shawn Yu, Nathan I. Nicely, Andrew Leaver‐Fay, William Kim, Brian A. Kuhlman

This paper designs orthogonal TCR β interfaces to prevent mispairing in dual-TCR therapeutics, achieving high pairing fidelity and demonstrating enhanced potency in targeting cancer antigens.

bioRxiv · Jan 2, 2026 · PreprintBioengineering