Ribosomes in RNA granules are stalled on mRNA sequences that are consensus sites for FMRP association.
Mina N. Anadolu, Jingyu Sun, Senthilkumar Kailasam, Kleanthi Chalkiadaki, Konstanze Simbriger, Jewel T-Y Li, Teodora Z. Markova, Seyed Mehdi Jafarnejad, François Lefebvre, Joaquı́n Ortega, Christos G. Gkogkas, Wayne S. Sossin
The paper identifies mRNA sequences that stall ribosomes in neurons, linking these sequences to FMRP association and stalled polysome function.
Journal of Neuroscience · Feb 27, 2023Peer-reviewedNeuroscience