Clive R. Bramham

This study uses single-particle tracking to show that ARC/ARG3.1 protein shuttles between cytoplasmic clusters and the nucleus in response to synaptic activation.

This study uses RCP-seq to analyze translation initiation dynamics in mouse brain tissues, revealing SSU poising and uORF effects on translational efficiency.

This study uses nanopore sequencing to analyze polyadenylation changes in rat hippocampi during long-term potentiation, revealing dynamic shifts in poly(A) tail length and composition.

This study identifies Arc/Arg3.1 as a regulator of PABPN1 nuclear speckles through direct binding, impacting mRNA processing during neuronal activity.

The paper develops a nanobody-based PLA to detect and quantify native Arc/Arg3.1 oligomers in hippocampal neurons, revealing constitutive and stimulus-regulated complexes.

This study shows that TENT2-dependent microRNA tailing affects synaptic transmission and excitatory/inhibitory balance in the hippocampus of mice.

This study shows that disrupting the TARP-ARC interaction stabilizes synaptic AMPA receptors and rescues fear memory deficits caused by social isolation in mice.

This study shows that eIF4E phosphorylation is essential for maintaining dentate gyrus LTP in vivo by recruiting β-catenin to the mRNA cap and enhancing Wnt pathway translation.

The paper develops and validates Arc nanobodies to study Arc protein dynamics and function, showing their ability to bind Arc and enable live-cell labeling and purification.

This study shows HSV-1 infection causes structural disassembly and functional deregulation in neurons through altered protein homeostasis and reduced spine scaffolding proteins.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.