Determinants of species-specific utilization of ACE2 by human and animal coronaviruses
Qingxing Wang, Sabrina Noettger, Qinya Xie, Chiara Pastorio, Alina Seidel, Janis A. Müller, Christoph Jung, Timo Jacob, Konstantin M. J. Sparrer, Fabian Zech, Frank Kirchhoff
The paper identifies key mutations in SARS-CoV-2 and bat coronaviruses that affect ACE2 receptor usage across different species and shows that vaccinated individuals' sera neutralize bat Sarbecovirus Spike proteins.
Communications Biology · Oct 17, 2023Peer-reviewedMolecular Biology