Author

Chiara Pastorio

Universität UlmORCID 0000-0002-4745-3678Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Frank KirchhoffiD· 4 shared Fabian ZechiD· 2 shared Konstantin M. J. SparreriD· 2 shared Alina SeideliD· 1 shared Andrea Preising· 1 shared Andy ChevignéiD· 1 shared Armando RodrígueziD· 1 shared Billy Michael Chelliah JebarajiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersImmunology

Frank KirchhoffORCID

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4 papers

Recent·Most cited

GPR15LG binds CXCR4 and synergistically modulates CXCL12-induced cell signaling and migration

Dan Albers, Sofya Novikova, Julio Vieyto‐Nuñez, Yasser Almeida‐Hernández, Chiara Pastorio, Florian Klassen, Dana Weiss, Pascal von Maltitz, Janeni Jaikishan, Moumita Datta, Hassan Jumaa, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer, Manish Kumar, Palash Chandra Maity, , Mirja Harms

This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.

Cell Communication and Signaling · May 20, 2025Peer-reviewedCell Biology

Retinol Binding Protein 4 reactivates latent HIV-1 via the JAK/STAT5 and JNK pathways

Chiara Pastorio, Khumoekae Richard, Manuel Hayn, Lennart Koepke, Andrea Preising, Nico Preising, Ludger Ständker, Matthew G. Fair, Jessicamarie Morris, Emmanouil Papasavvas, Honghong Sun, Armando Rodríguez, Karam Mounzer, Sebastian Wiese, Pablo Tebas, , Frank Kirchhoff

This study identifies Retinol Binding Protein 4 (RBP4) as a natural activator of latent HIV-1 through JAK/STAT5 and JNK pathways, offering a new strategy for reactivating viral reservoirs.

bioRxiv · Feb 26, 2025 · PreprintImmunology

Attenuated replication and damaging effects of SARS-CoV-2 Omicron in an intestinal epithelial barrier model

Meta Volčič, Rayhane Nchioua, Chiara Pastorio, Fabian Zech, Isabell Haußmann, Daniel Sauter, Clarissa Read, Paul Walther, Frank Kirchhoff

This study compares the effects of SARS-CoV-2 early strains and Omicron variants on intestinal barrier function using a human gut epithelial model, finding Omicron causes less damage.

Journal of Medical Virology · Jul 1, 2024Peer-reviewedImmunology

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

Qingxing Wang, Sabrina Noettger, Qinya Xie, Chiara Pastorio, Alina Seidel, Janis A. Müller, Christoph Jung, Timo Jacob, Konstantin M. J. Sparrer, Fabian Zech, Frank Kirchhoff

The paper identifies key mutations in SARS-CoV-2 and bat coronaviruses that affect ACE2 receptor usage across different species and shows that vaccinated individuals' sera neutralize bat Sarbecovirus Spike proteins.

Communications Biology · Oct 17, 2023Peer-reviewedMolecular Biology