Dominique Dorin

FIKK1, a member of the FIKK kinase family, phosphorylates VAR2CSA and regulates adhesion of Plasmodium falciparum-infected erythrocytes to the placental receptor CSA

This study identifies FIKK1 as a kinase that phosphorylates VAR2CSA, enhancing its binding to CSA and promoting placental malaria virulence.

Taurine is a Natural Host Cytoadhesion Inhibitor in Asymptomatic Malaria Cases

This study identifies taurine as a host metabolite that inhibits malaria parasite cytoadhesion in asymptomatic infections, suggesting its potential as a therapeutic target.

Casein Kinases 2-dependent phosphorylation of the placental ligand VAR2CSA regulates Plasmodium falciparum-infected erythrocytes cytoadhesion

This study identifies Casein Kinase 2 as the kinase responsible for phosphorylating VAR2CSA, enhancing its CSA binding and infected erythrocyte adhesion.