Xinan Holly Yang

This study shows that Tbx3 and Tbx5 work together to control the function and molecular identity of the adult ventricular conduction system in mice, leading to conduction defects when both are missing.

This study identifies Hedgehog signaling as a regulator of differentiation timing through a heterochronic gene regulatory network in cardiac and neural lineages.

This study identifies a gene regulatory network involving Tbx5, RA, Hedgehog, and Wnt signaling that coordinates cardiopulmonary development.

The paper introduces BioTIP, a method to identify critical transition signals in gene expression data, showing it accurately detects bifurcations and identifies key transcription factors involved in differentiation.

The paper introduces a new computational pipeline, Tuxedo, for analyzing nuclear RNA-seq data, which identifies chromatin-enriched RNAs (cheRNAs) and characterizes their cis-regulatory roles.