Patrick S. Mitchell

Viral subversion of the host ubiquitin proteasome system is broadly sensed by the NLRP1 inflammasome

The paper identifies viral E3 ligase activity as a conserved trigger of NLRP1 inflammasome activation, expanding effector-triggered immunity against viral pathogens.

TAK1 integrates the NLRP1 inflammasome into the innate immune response to double-stranded RNA

This study shows TAK1 activates the NLRP1 inflammasome in response to dsRNA, linking it to inflammatory responses in viral infection and autoimmunity.

Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome

This study identifies OspF as a Shigella effector that inhibits NAIP-NLRC4 inflammasome activation by blocking p38-dependent priming, explaining human susceptibility to Shigella.

CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

The paper investigates CARD8 inflammasome activation during HIV-1 cell-to-cell transmission, showing it depends on viral protease activity and not NLRP3.