Author

Joy Mecano

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Megan L. SchalleriD· 2 shared Safa BeydouniD· 2 shared Scott F. LeiseriD· 2 shared Ajay BhatiD· 1 shared Amara Bugarin-Lapuz· 1 shared Angela M. TuckowskiiD· 1 shared Charles R. EvansiD· 1 shared Daniel Andrew BeardiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPhysiology

Megan L. SchallerORCID

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2 papers

Recent·Most cited

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

Megan L. Schaller, Madeline M. Sykes, Joy Mecano, Sumeet A. Solanki, Wesley Huang, Ryan James Rebernick, Safa Beydoun, Emily Wang, Amara Bugarin-Lapuz, Yatrik Madhukar Shah, Scott F. Leiser

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2025Peer-reviewedPhysiology

FMO rewires metabolism to promote longevity throughtryptophan and one carbon metabolism

Hyo Sub Choi, Ajay Bhat, Marshall B. Howington, Megan L. Schaller, Rebecca L. Cox, Shijiao Huang, Safa Beydoun, Hillary A. Miller, Angela M. Tuckowski, Joy Mecano, Elizabeth S. Dean, Lindy Jensen, Daniel Andrew Beard, Charles R. Evans, Scott F. Leiser

This study identifies FMO-2's role in promoting longevity in C. elegans by rewiring one carbon metabolism and tryptophan metabolism, linking a single enzyme to metabolic pathways involved in lifespan extension.

bioRxiv · Jun 18, 2021 · PreprintMolecular Biology