Targeting epilepsy with photopharmacology in human brain tissue
Mayan Baues, Ahmed Elgokha, Mai My Hong Nguyen, Merlin Schwering-Sohnrey, Tongil Ko, Florian Schwermer, Filomena Perri, Thoralf Opitz, Tony Kelly, Gilles Huberfeld, Valeri Borger, Matthias B. Schneider, Rainer Surges, Heinz Beck, D. Trauner, , Michael Wenzel
This study evaluates photopharmacology agents in human and mouse brain tissue to control epilepsy, finding that caged propofol suppresses epileptiform activity across species.
bioRxiv · Feb 16, 2026 · PreprintPharmacology & Toxicology