Johannes M. F. G. Aerts

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

This paper creates a humanised GBA-L444P mouse model to study GBA1 mutations in Parkinson's, finding gain-of-function effects on dopamine release and loss-of-function effects on alpha-synuclein pathology.

This study investigates the role of glycosphingolipids in autoimmune manifestations and myeloma in Gaucher disease using a mouse model and finds that CD1 molecules regulate inflammation and tumour formation but not monoclonal immunoglobulin production.

The paper identifies modifier pathways for inborn errors of metabolism using multiomic data and gene regulatory networks from healthy populations.