Bradley M. Roberts

A human GBA-L444P transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson's disease

This paper creates a humanised GBA-L444P mouse model to study GBA1 mutations in Parkinson's, finding gain-of-function effects on dopamine release and loss-of-function effects on alpha-synuclein pathology.

Gabapentinoids promote striatal dopamine release and rescue multiple deficits of a mouse model of early Parkinson's

This study shows gabapentinoids enhance dopamine release in a Parkinson's mouse model and improve movement deficits by modulating calcium and GABAergic signaling.

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes

The paper reveals that striatal astrocytes rapidly modulate cholinergic interneurons and dopamine release through subsecond calcium dynamics in mice and humans.

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2

This study investigates how mTORC1 and mTORC2 differentially regulate dopamine neuron morphology and function in mice, revealing distinct effects on structure, excitability, and dopamine output.

Dopamine release in nucleus accumbens is under tonic inhibition by adenosine A1 receptors regulated by astrocytic ENT1 and dysregulated by ethanol

This study investigates how adenosine A1 receptors inhibit dopamine release in the nucleus accumbens, showing that astrocytic ENT1 regulates this inhibition and that ethanol disrupts it.

Astrocytic striatal GABA transporter activity governs dopamine release and shows maladaptive downregulation in early parkinsonism

The paper investigates the role of astrocytic GABA transporters in regulating dopamine release in the striatum and shows their downregulation in early parkinsonism.

Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter

The paper investigates short-term plasticity in dopamine release in the striatum, finding that it is primarily governed by axonal properties and the dopamine transporter rather than initial release levels.