ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
T Lymphocyte-Specific Deletion of SHP1 and SHP2 Promotes Activation-Induced Cell Death of CD4+ T Cells and Impairs Antitumor Response
Connor Foster, Jasper Du, Oscar J. Pundel…·Benjamin G. Neel
This study shows that deleting SHP1 and SHP2 in T cells increases CD4+ T cell activation-induced cell death and reduces antitumor responses, with SHP2 loss enhancing anti-PD-1 therapy.
10 citations