Amelia Farinas

Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

The paper uses plasma proteomics to estimate biological age of multiple cell types and links aging signatures to disease risk and mortality across 60,000 individuals.

Spatial and molecular insights into microglial roles in cerebellar aging

The paper investigates age-related changes in cerebellar microglia using single-nuclei RNA sequencing and MERFISH, finding enhanced neuroprotective immune activation and proximity to granule cells in aged mice.

Synapse protein signatures in cerebrospinal fluid and plasma predict cognitive maintenance versus decline in Alzheimers disease

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

Glia detect and mount a protective response to loss of dendrite substructure integrity in C. elegans

The paper shows that glia in C. elegans detect and respond to dendrite structure damage by altering gene expression and secreting proteins, with specific proteins required for this response.

Cell non-autonomous control of autophagy and metabolism by glial cells

This study shows glial cells control autophagy and metabolism in C. elegans through non-autonomous activation of HLH-30 in the intestine.