Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria
Elisabetta Cacace, Manuela Tietgen, Meike Steinhauer, André Mateus, Tilman G. Schultze, Marina Eckermann, Marco Galardini, Vallo Varik, Alexandra Koumoutsi, Jordan J. Parzeller, Federico Corona, Askarbek N Orakov, Michael R. Knopp, Amber Brauer-Nikonow, Peer Bork, , Stephan Göttig
This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.
Nature Communications · Apr 22, 2025Peer-reviewedMicrobiology