Alexandra Koumoutsi

This study reveals that phage T7 kinase broadly phosphorylates host and phage proteins, disabling bacterial defense systems through widespread phosphorylation.

This study identifies nitroxoline's broad antibacterial activity against Gram-negative bacteria, its mode of action involving metal homeostasis and outer membrane disruption, and resistance mechanisms across multiple species.

The paper predicts growth defects in Escherichia coli strains using genetic variant impact models and gene function data, achieving reliable predictions for up to 38% of tested conditions.