Michael P. O’Donnell

This study evaluates AAV serotype transduction efficiency in murine dorsal root ganglia, finding that AAV8, AAV9, and PHP.S show comparable efficiency but distinct neuronal volume distributions.

This study identifies ciliary trafficking mechanisms and functions of RIC-8 in C. elegans and mammalian cilia, showing its role in chemosensory responses and ciliogenesis.

FLInt 2.0 improves transgene integration in C. elegans by reducing false positives through targeted Cas9 cutting and fluorescence preservation during repair events.

This study identifies an ancient monoaminergic system in sponges that coordinates contractility through tryptamine signaling, predating neurons.

This study identifies a mechanism in C. elegans where lipidated neurohormones couple neurotransmitter signaling with lipid metabolism to regulate behavior.

This study investigates how cilia structure and intraflagellar transport (IFT) differentially modulate chemosensory responses in C. elegans neurons.

This study shows that developmental dauer arrest in C. elegans alters chemoreceptor expression, leading to changes in olfactory behavior and attraction to food-related odorants.

This study shows that Caenorhabditis elegans uses hydrogen peroxide sensing to avoid harmful bacteria and find food-rich niches with lower H2O2 levels.

This study shows that enteric bacteria produce tyramine, which modulates host sensory behavior and food choice in C. elegans by mimicking host neurotransmitters.

This paper shows that TORC2 in C. elegans gut communicates feeding state to the brain, regulating developmental decisions and foraging behaviors through hormonal signaling.