Author

Shikha Shukla

Buck Institute for Research on AgingORCID 0000-0001-8322-1703Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A Kifle· 1 shared Aamir NaziriD· 1 shared Aikaterini Stratigi· 1 shared Anand RaneiD· 1 shared Arunabh SarkariD· 1 shared Chaska C. WaltoniD· 1 shared Georgia Woods· 1 shared Janet E. RichmondiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

A Kifle

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3 papers

Recent·Most cited

NeuroscienceGeroSciencePeer-reviewedMar 6, 2026

A Compound Enhancing Lysosomal Function Reduces Tau Pathology, Microglial Reactivity and Rescues Working Memory in 3xTg AD Mice

Zachary Mayeri, Georgia Woods, Anand Rane…·Julie Kay Andersen

This study evaluates a natural compound (MIC) that reduces tau pathology and microglial reactivity in 3xTgAD mice and rescues working memory, suggesting it as a potential therapeutic for Alzheimer's disease.

1 citation

mouseexperimental assay

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NeuroscienceJournal of NeurosciencePeer-reviewedFeb 7, 2025

Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans.

Aikaterini Stratigi, Miguel Soler-García, Mia Krout…·Patrick Laurent

The paper identifies PHAC-1 as a regulator of synaptic transmission in C. elegans and shows that DEE70 variants disrupt cholinergic signalling at the neuromuscular junction.

1 citation

C. eleganselectronic health records

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NeurosciencebioRxivPreprintJul 30, 2020

Targeted downregulation of estradiol binding Na+/H+ exchanger nhx-2, mimics calorie restriction, extends reproductive longevity and ameliorates effects associated with alpha synuclein aggregation in C. elegans

Shikha Shukla, Lalit Kumar, Arunabh Sarkar…·Aamir Nazir

This study identifies nhx-2 as a modulator that extends reproductive longevity and ameliorates alpha-synuclein aggregation effects in C. elegans by mimicking dietary restriction.

4 citations

C. elegansstatistical model

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