Christoph M. Tang

DarHTG is a tripartite phage defence system for purine DNA base ADP-ribosylation

The paper describes DarHTG, a bacterial phage defense system that ADP-ribosylates double-stranded DNA using a helicase co-toxin, and identifies two subclasses with distinct target bases.

Emergence of short-lived meningococci causing focal epidemics can be associated with gene transfer from carriage-associated Neisseria

A 21-case nightclub-linked meningococcal outbreak variant differed from its closest relatives by horizontal gene transfer from carriage-associated Neisseria, affecting iron acquisition and type IV pili genes.

A murine model of Shigella sonnei intestinal colonization

This paper develops a murine model of Shigella sonnei intestinal colonization and identifies factors contributing to its persistence and immune response.

Genomic epidemiology of Neisseria gonorrhoeae isolates from the G-ToG clinical trial, 2014-2016

The paper analyzes whole genome sequences of Neisseria gonorrhoeae isolates from the G-ToG trial to characterize gonococcal diversity and AMR patterns in England, showing sexual network-driven phylogenetic structure and AMR differences between transmission groups.

Phase-variable restriction modification systems dynamically regulate plasmid transmission in Neisseria gonorrhoeae

The paper shows phase-variable restriction modification systems in Neisseria gonorrhoeae limit plasmid transmission, affecting antimicrobial resistance spread.

Real-time visualisation of the intracellular dynamics of Shigella virulence plasmid

This study visualizes the intracellular dynamics of Shigella sonnei's virulence plasmid pINV in real-time using fluorescent tagging.

The origin and evolution of the gonococcal beta-lactamase plasmid, and implications for public health

This study investigates the origin and evolution of the gonococcal beta-lactamase plasmid pbla, showing its acquisition from Haemophilus ducreyi and its role in antibiotic resistance, with implications for public health.

An antibody-drug conjugate exploiting a bacterial immune evasion mechanism is effective against multidrug resistant Neisseria gonorrhoeae

This paper develops an antibody-drug conjugate targeting Neisseria gonorrhoeae that uses bacterial immune evasion to selectively kill drug-resistant strains.

DMB labelling for detection and analysis of capsular polysaccharides

The paper introduces a biochemical method to detect and analyze capsular polysaccharides in bacteria, improving upon traditional serotyping assays.

Structural Design of Chimeric Antigens for Multivalent Protein Vaccines

This paper designs chimeric antigens for multivalent protein vaccines by combining immunogenic epitopes from integral membrane proteins with a molecular scaffold, showing efficacy in mice against meningococcal disease.