Sita Ramaswamy

This study shows that MDA5 senses HIV-1 unspliced RNA based on 5' cap structure and nuclear export pathway, revealing how the virus evades innate immunity.

This study identifies the MDA5-IRF5 axis as critical for HIV-1 icRNA-induced inflammatory responses in macrophages, with IRF5 mediating enhanced IP-10 expression in older individuals.

This study shows that ocln regulates mitochondrial function and innate immunity, impacting HIV infection and ischemic stroke outcomes through RIG-1 signaling.