Kyungsub Kim

This paper identifies OspC2 and OspC3 as Shigella effectors that specifically target Caspase-5 and Caspase-4, respectively, through their PCS domains, revealing evolutionary adaptations in host and pathogen interactions.

This study identifies OspF as a Shigella effector that inhibits NAIP-NLRC4 inflammasome activation by blocking p38-dependent priming, explaining human susceptibility to Shigella.