Author

Lisa Goers

Harvard UniversityORCID 0000-0002-1585-8726Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Cammie F. LesseriD· 2 shared Kyungsub KimiD· 2 shared Elizabeth A TurcotteiD· 1 shared Jonathan N. PrunedaiD· 1 shared Kevin EislmayriD· 1 shared Marcos Antonio Valdespino DiaziD· 1 shared Michele E. MuscoloiD· 1 shared Patrick S. MitchelliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Cammie F. LesserORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Differential targeting of human pyroptotic Caspase-5 and Caspase-4 by Shigella OspC2 and OspC3

Kyungsub Kim, Marcos Antonio Valdespino Diaz, Rowan Karr, Michele E. Muscolo, Lisa Goers, Truelian Yu, Tera C. Levin, Jonathan N. Pruneda, Cammie F. Lesser

This paper identifies OspC2 and OspC3 as Shigella effectors that specifically target Caspase-5 and Caspase-4, respectively, through their PCS domains, revealing evolutionary adaptations in host and pathogen interactions.

mBio · Feb 18, 2026Peer-reviewedMicrobiology

Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome

Elizabeth A Turcotte, Kyungsub Kim, Kevin Eislmayr, Lisa Goers, Patrick S. Mitchell, Cammie F. Lesser, Russell E. Vance

This study identifies OspF as a Shigella effector that inhibits NAIP-NLRC4 inflammasome activation by blocking p38-dependent priming, explaining human susceptibility to Shigella.

Proceedings of the National Academy of Sciences · Jan 14, 2026Peer-reviewedImmunology