Ralf Erdmann

Evolutionary Remodelling of a Remnant GET-Pathway Factor into PEX38, a Novel and Essential Peroxin in Euglenozoa

The paper identifies PEX38 as a novel, essential peroxin in Euglenozoa, evolved from a remnant GET-pathway factor, and highlights its role in peroxisomal membrane protein targeting and potential as a therapeutic target.

Identification of small molecule inhibitors of Trypanosoma PEX15--PEX6 interaction

This study identifies small molecule inhibitors targeting the TbPEX6-TbPEX15 interaction in trypanosomatid parasites, showing trypanocidal activity in vitro.

Role of AAA-ATPase Cdc48p in Peroxisomal Quality Control

The paper identifies Cdc48p as a key component of the RADAR pathway in yeast, which degrades misfolded peroxisomal receptors.

An inhibitor targeting glycosome membrane biogenesis kills Leishmania parasites

This study identifies an FDA-approved inhibitor that targets glycosome membrane biogenesis in Leishmania parasites, effectively killing them including amastigote forms.

Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate

The paper reports cryoEM structures of the Pex1/Pex6 ATPase complex from yeast, revealing how it translocates substrates through conformational changes and mechanical force propagation.

Towards the molecular architecture of the peroxisomal receptor docking complex

The paper provides the first structural characterization of the yeast peroxisomal docking complex Pex14p/Pex17p, revealing its subunit organization and potential role in import pore formation.