The orphan receptor IL-17RD is a negative regulator of RIG-I-like receptor-dependent antiviral innate immunity and restrains SARS-CoV-2-induced lung inflammation
Firas El-Mortada, Jiunn Roy, Charlotte Girondel, Florence Dô, Ana Claudia Andrade, Émile Lacasse, Isabelle Dubuc, Philippe P. Roux, Guillaume St‐Jean, Baptiste Demey, Nathalie Labrecque, Louis Flamand, Sylvain Meloche, Marc J. Servant
This study identifies IL-17RD as a negative regulator of RIG-I-like receptor-dependent antiviral immunity, showing it limits SARS-CoV-2-induced lung inflammation.
bioRxiv · Sep 9, 2026 · PreprintMicrobiology