Author

William T. Wickner

Dartmouth CollegeORCID 0000-0001-8431-0468Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:yeast· 2 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Amy S OrriD· 2 shared Karina Lopes· 2 shared Axel T. BrüngeriD· 1 shared Bharti SingaliD· 1 shared Elizabeth A. MontabanaiD· 1 shared Fang LiuiD· 1 shared Garvey MckenzieiD· 1 shared Jerry O'Dwyer· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

Amy S OrrORCID

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3 papers

Recent·Most cited

BiochemistryMolecular Biology of the CellPeer-reviewedNov 19, 2025

Functional assembly of the Qc-SNARE with Sec18 and Sec17 on membranes

Amy S Orr, Karina Lopes, Jerry O'Dwyer, William T. Wickner

The paper investigates the functional assembly of Qc-SNARE with Sec18 and Sec17 on membranes, revealing their roles in yeast vacuolar fusion and ATP hydrolysis.

DOI 10.1091/mbc.e25-10-0474

yeastexperimental assay

𝕏 PostBluesky

BiophysicsNature Structural & Molecular BiologyPeer-reviewedJul 2, 2025

SNARE disassembly requires Sec18/NSF side-loading

Yousuf A. Khan, K. Ian White, Richard A. Pfuetzner…·Axel T. Brünger

The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.

9 citations

yeaststructural biology

𝕏 PostBluesky

BiochemistrybioRxivPreprintNov 15, 2024

Membrane fusion reactions limited by defective SNARE zippering or stiff lipid fatty acyl composition have distinct requirements for Sec17, Sec18, and adenine nucleotide

Karina Lopes, Amy S Orr, William T. Wickner

This study investigates how defective SNARE zippering or stiff lipid fatty acyl composition affect membrane fusion and the roles of Sec17 and Sec18 in overcoming these impediments.

DOI 10.1101/2024.11.15.623832

experimental assaycell signaling & trafficking

𝕏 PostBluesky