Author

Kristin L. Lenz

Washington University in St. LouisORCID 0009-0002-4873-4233Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

Farshid GuilakiD· 3 shared Kelsey H. CollinsiD· 3 shared Arin K. OestreichiD· 2 shared Bethany A. AndokoiD· 2 shared Bo ZhangiD· 2 shared Hope D. WelhaveniD· 2 shared Joseph B. LesnakiD· 2 shared Theodore John PriceiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersPhysiology

Farshid GuilakORCID

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3 papers

Recent·Most cited

Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling

Hope D. Welhaven, Elise K Truchan, Kristin L. Lenz, Bethany A. Andoko, Malik A. Alhadi, Michael R. Mazzucco, Reyna E. Villa, Arin K. Oestreich, Bo Zhang, Dana E. Orange, Joseph B. Lesnak, Theodore John Price, Farshid Guilak, Kelsey H. Collins

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

Osteoarthritis and Cartilage · Oct 1, 2026Peer-reviewedPhysiology

Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

Hope D. Welhaven, Joseph B. Lesnak, Kristin L. Lenz, Bethany A. Andoko, Arin K. Oestreich, Ashley N. Plumb, Katelyn E. Sadler, Luke E. Springer, Jacob G. Brockert, Darren Dumlao, Antonina M. Akk, Xiaobo Wu, Huimin Yan, Bo Zhang, Stephen P. Messier, , Kelsey H. Collins

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

bioRxiv · Mar 21, 2026 · PreprintPhysiology

Chondrocyte-Specific Knockout of Piezo1 and Piezo2 Protects Against Post-Traumatic Osteoarthritis Structural Damage and Pain in Mice

Erica V. Ely, Kristin L. Lenz, Sophie G. Paradi, Seth Ack, Abraham Behrmann, Sarah Dunivan, Lauryn A. Braxton, Wolfgang Liedtke, Yong Chen, Kelsey H. Collins, Farshid Guilak

This study shows that knocking out Piezo1 and Piezo2 in chondrocytes protects against post-traumatic osteoarthritis structural damage and pain in mice.

Arthritis Research & Therapy · Jul 19, 2025Peer-reviewedPhysiology