This study identifies RICTOR as a regulator of dietary plasticity in C. elegans, showing it modulates longevity through a methionine cycle-mitophagy axis influenced by bacterial vitamin B12.

Nature Communications · Sep 14, 2026Peer-reviewedCell Biology

A yeast model of 5-oxoproline accumulation reveals a general toleration to 5-oxoproline

Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat

The paper creates a yeast model of 5-oxoproline accumulation and finds no significant oxidative stress response, suggesting a need to reevaluate previous assumptions about 5-OP's role.

FEBS Open Bio · Jul 15, 2026Peer-reviewedSystems Biology

Phospholipids that plug the pores of cholesteryl ester transfer protein control its lipid transfer dynamics

Sukriti Sacher, Praveen Singh, Abhishek Mukherjee, Akash Kumar Bhaskar, Kausik Chakraborty, Laurent Counillon, Shantanu Sengupta, Mallorie Poët, Arjun Ray

This paper identifies phospholipids that regulate lipid transfer through CETP by enabling a novel 'gliding' mechanism, revealing their critical role in lipid movement and providing new therapeutic insights.

bioRxiv · Sep 4, 2025 · PreprintBiophysics

Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling

Sabnam Sahin Rahman, Shreya Bhattacharjee, Simran Motwani, Govind Prakash, Rajat Ujjainiya, Shivani Chitkara, Tripti Nair, Rachamadugu Sai Keerthana, Shantanu Sengupta, Arnab Mukhopadhyay

This study shows that the methionine cycle in serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling pathway in C. elegans.

Nature Communications · Jun 2, 2025Peer-reviewedCell Biology

Integrative plasma lipidomics and proteomics profiling to decipher potential biomarkers of dilated cardiomyopathy

Shubham Saha, Praveen Singh, Abhi Dutta, Anurag Raj, Mamta Rathore, Deepika Jindal, Hiteshi Vaidya, Santoshi Kumari, Prakash Chand Negi, Shantanu Sengupta, Sandeep Seth, Trayambak Basak

This study identifies lipidomic and proteomic biomarkers for dilated cardiomyopathy using mass spectrometry and machine learning, achieving high diagnostic accuracy.

bioRxiv · Apr 13, 2025 · PreprintSystems Biology

DIGEST: An online tool for designing of multiple reaction monitoring assays

Prutyay Gautam, Praveen Singh, Mrinal, Akash Kumar Bhaskar, Sukriti Sacher, Yashesh Dagar, Trayambak Basak, Shantanu Sengupta, Arjun Ray

DIGEST is a web tool that designs MRM transitions for proteomics by predicting peptide fragmentation patterns and selecting optimal ion pairs to improve assay specificity and reduce experimental time.

bioRxiv · Nov 27, 2023 · PreprintBioinformatics

Chronic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver

Manoj Kumar Singh, Rijith Jayarajan, Swati Varshney, Sindhuri Upadrasta, Archana Kumari Singh, Rajni Yadav, Vinod Scaria, Shantanu Sengupta, Dhanasekaran Shanmugam, S. Shalimar, Sridhar Sivasubbu, Sheetal Gandotra, Chetana Sachidanandan

This study shows chronic IL6 overexpression in zebrafish causes liver fat accumulation through glycolysis deregulation, suggesting inflammation as a cause for obesity-independent NAFLD.

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · Feb 15, 2021Peer-reviewedMolecular Biology

Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing

Subhoshree Ghose, Sourav Ghosh, Vinay Singh Tanwar, Priya Tolani, Rintu Kutum, Anju Sharma, Nitin Bhardwaj, Shamsudheen Karuthedath Vellarikkal, Ankit Verma, Rijith Jayarajan, Debasis Dash, Sridhar Sivasubbu, Vinod Scaria, Sandeep Seth, Shantanu Sengupta

The paper identifies methylation changes in CAD-related genes in young patients compared to controls, suggesting potential epigenetic markers for CAD risk.

Gene · Sep 6, 2019Peer-reviewedGenomics