Pim J. Huis in ’t Veld

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

The paper shows that Ska and Ndc80 complexes form oligomers to stabilize microtubule ends during mitosis, with a mutation disrupting Ska:Ska interactions and impairing stability.

This study identifies a role for the TRiC/CCT chaperonin in folding meiotic HORMAD proteins into chromosome axes necessary for crossing over.

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.

The paper investigates the phosphorylation-dependent Ska-Ndc80 interaction and its role in microtubule tracking and force-coupling during chromosome segregation.