Author

Lauren de Haan

University Medical Center GroningenORCID 0009-0004-2196-9686Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1

Frequent Co-Authors

Bert van de KooijiD· 2 shared Femke J. BakkeriD· 2 shared H. Rudolf de BoeriD· 2 shared Marcel A.T.M. van VugtiD· 2 shared Pim J. Huis in ’t VeldiD· 2 shared Alejandro García López· 1 shared Angela GrafiD· 1 shared Anna DekkeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Bert van de KooijORCID

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2 papers

Recent·Most cited

CIP2A tetramerization is required for mitotic DNA repair

Lauren de Haan, Rebecca Schneeweiss, Marco Barazas, Milo L. Kaptein, Femke J. Bakker, Anna Dekker, Ekaterina Ovcharenko, Soraya S. Beneddine, Angela Graf, Dimitra Paouneskou, Bert van de Kooij, Raimundo Freire, Verena Jantsch, Jos Jonkers, H. Rudolf de Boer, , Pim J. Huis in ’t Veld

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

bioRxiv · Aug 24, 2026 · PreprintCell Biology

CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity

Lauren de Haan, Sietse J. Dijt, Alejandro García López, Dan Ruan, Femke J. Bakker, Marieke Everts, Harry M. Warner, Frank N. Mol, H. Rudolf de Boer, Pim J. Huis in ’t Veld, Bert van de Kooij, Rifka Vlijm, Marcel A.T.M. van Vugt

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.

bioRxiv · Apr 3, 2025 · PreprintCell Biology