Russell D. Wolfinger

snATAC-Express infers Gene Expression from Prioritized Chromatin Accessibility Peaks using Machine Learning

The paper develops a machine learning pipeline to infer gene expression from chromatin accessibility peaks using single nuclear multi-omic data, finding that important peaks are enriched in GWAS variants for inflammatory bowel disease and lupus.

Orchestrating and sharing large multimodal data for transparent and reproducible research

The paper introduces a cloud-based platform called ORCESTRA for reproducible processing and sharing of multimodal biomedical data in a FAIR manner.

A cancer pharmacogenomic screen powering crowd-sourced advancement of drug combination prediction

The paper presents a large-scale cancer pharmacogenomic screen with 11,576 experiments on 910 drug combinations across 85 cancer cell lines, enabling crowd-sourced prediction of synergistic drug pairs and biomarkers.

A community-based collaboration to build prediction models for short-term discontinuation of docetaxel in metastatic castration-resistant prostate cancer

This paper presents a crowdsourced challenge to predict early discontinuation of docetaxel in mCRPC patients using clinical data from multiple trials, finding that ensemble models outperform individual models.

Reverse-engineering human olfactory perception from chemical features of odor molecules

The paper demonstrates that machine learning can accurately predict odor perception from molecular features, enabling reverse-engineering of smell.