Nadja Zeitzschel

This study investigates how the wedge domain of PIEZO1 contributes to its inactivation through structural and functional analyses.

This study uses 3D-MINFLUX nanoscopy and electrophysiology to show Yoda1 activates PIEZO1 through two distinct allosteric sites, revealing separate pathways for activation and modulation.

This study uses MINFLUX nanoscopy to show PIEZO1 channels create membrane invaginations and exhibit conformational changes linked to function and cytoskeletal architecture in intact cells.

This paper introduces an optogenetic voltage-clamp technique for precise control of cellular voltage in live animals, demonstrating its application in C. elegans and rat neurons.

BiPOLES is an optogenetic tool that allows bidirectional control of neuronal activity using two different light colors, enabling both excitation and inhibition of the same neurons in a single experiment.