Lucas Roettger

This study investigates how the wedge domain of PIEZO1 contributes to its inactivation through structural and functional analyses.

This study uses 3D-MINFLUX nanoscopy and electrophysiology to show Yoda1 activates PIEZO1 through two distinct allosteric sites, revealing separate pathways for activation and modulation.

This study uses MINFLUX nanoscopy to show PIEZO1 channels create membrane invaginations and exhibit conformational changes linked to function and cytoskeletal architecture in intact cells.