George A. O’Toole

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

This study determines the structure of CdrA, a fibrillar adhesin in Pseudomonas aeruginosa, revealing its role in biofilm formation and identifying targets for inhibition.

This study investigates microbial dysbiosis in children with cystic fibrosis, identifying glycerol as a driver of altered microbial competition and linking colibactin production to increased colorectal cancer risk.

This study examines how Bacteroides colonization affects gut and systemic health in mice, revealing sex-dependent immune responses and macrophage marker changes in specific gut regions.

This study uses culturomics to analyze gut microbiota in CF and non-CF individuals, finding higher bacterial loads and spatially specific dysbiosis in CF mucosal samples.

This paper introduces PolypCure, a hydrogel adhesive dressing that rapidly seals and hemostases colon wounds post-polypectomy, showing long-term stability and biocompatibility in an in vivo model.

This study profiles bile acids in stool from children with and without cystic fibrosis, revealing differences in BA species and microbial metabolism, and highlights the ferret model's suitability for BA research in CF.

This study identifies a cross-feeding mechanism between Pseudomonas aeruginosa and Prevotella melaninogenica in a CF lung polymicrobial community, where metabolites from mucin degradation support P. melaninogenica survival.

This study shows that disrupting phage liquid crystalline droplets in Pseudomonas aeruginosa biofilms eliminates antibiotic tolerance by promoting antibiotic diffusion.

This study identifies key bacterial proteins involved in flagellar-mediated surface sensing in P. aeruginosa, showing their role in regulating c-di-GMP levels and biofilm formation.

This study shows that in vitro biofilm formation by Pseudomonas fluorescens does not fully predict its ability to protect plants against pathogens in the rhizosphere.

This study investigates how serum albumin and calcium inhibit biofilm formation in Bordetella bronchiseptica through two independent mechanisms involving c-di-GMP and adenylate cyclase toxin.

This study shows that disrupting the EcfAAT transporter in Streptococcus sanguinis increases antibiotic susceptibility and alters metal and membrane homeostasis.

The paper identifies Dpr-mediated H2O2 resistance as critical for Streptococcus sanguinis survival in a polymicrobial CF airway model.

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

This study identifies altered stool microbiota in infants with cystic fibrosis, linking reduced Bacteroides and Bifidobacterium to immune-related metabolic pathways and systemic inflammation.

This paper identifies a novel retention mechanism for LapA, a type-1 secreted adhesin in Pseudomonas fluorescens, which is anchored at the cell surface via a TolC-like pore and regulated by a periplasmic protease.