Mark S. Sundrud

Ileitis abolishes tolerogenic functions of the enterohepatic bile acid pool

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

Constitutive androstane receptor directs developing Th1 cells towards the Tr1 lineage

This study shows CAR promotes Tr1 lineage commitment in Th1 cells during intestinal inflammation, with IL-27 and glucocorticoids enhancing this effect.

Mucosal-associated invariant T cells support IL-15-dependent Treg response in skin injury and promote resolution of skin inflammation

This study identifies MAIT cells as regulators of Treg responses in skin inflammation, showing their ability to resolve inflammation through IL-15-dependent mechanisms.

Profiling Bile Acids in the Stools of Humans and Animal Models of Cystic Fibrosis

This study profiles bile acids in stool from children with and without cystic fibrosis, revealing differences in BA species and microbial metabolism, and highlights the ferret model's suitability for BA research in CF.

Clonal Parabacteroides from Gut Microfistulous Tracts as Transmissible Cytotoxic Succinate-Commensal Model of Crohn's Disease Complications

The paper identifies clonal Parabacteroides distasonis isolates from CD-associated gut fistulas that exhibit pathogenic traits in mouse models and show potential for transmissibility and adaptation to CD-like ileitis.

Quantifying forms and functions of intestinal bile acid pools in mice

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.