Author

Courtney Lynn Hegner

Scripps Research InstituteORCID 0000-0002-8971-4469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Akshaya BalasubramanianiD· 3 shared Henry D. DionneiD· 3 shared Mark S. SundrudiD· 3 shared Alexander Rodriguez‐PalaciosiD· 2 shared Amber Delmas EliasoniD· 2 shared B. JoNell Hamilton· 2 shared Casey Todd WeaveriD· 2 shared Daniel SchultziD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Akshaya BalasubramanianORCID

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3 papers

Recent·Most cited

Ileitis abolishes tolerogenic functions of the enterohepatic bile acid pool

Zhiping Xiao, Kôichi Sudô, Amber Delmas Eliason, Jiabao Liu, Paola Munoz‐Tello, Henry D. Dionne, Fiona Nguyen, Alexander D. Hondros, 楊惠娟, B. JoNell Hamilton, Akshaya Balasubramanian, Courtney Lynn Hegner, Gilian Jacobsen, Erin M. Tonzi, Ila K. Kaul, , Mark S. Sundrud

The paper shows that ileitis disrupts bile acid (BA) pool balance, altering immune regulation by affecting BA receptor interactions and Th17 cell function.

bioRxiv · Sep 18, 2026 · PreprintImmunology

Constitutive androstane receptor directs developing Th1 cells towards the Tr1 lineage

Courtney Lynn Hegner, Blake F. Frey, Akshaya Balasubramanian, Henry D. Dionne, 楊惠娟, B. JoNell Hamilton, Casey Todd Weaver, Mark S. Sundrud

This study shows CAR promotes Tr1 lineage commitment in Th1 cells during intestinal inflammation, with IL-27 and glucocorticoids enhancing this effect.

bioRxiv · Jul 26, 2026 · PreprintImmunology

Quantifying forms and functions of intestinal bile acid pools in mice

Koichi Sudo, Amber Delmas Eliason, Shannon M. Soucy, Kaitlyn E. Barrack, Jiabao Liu, Akshaya Balasubramanian, Chengyi Jenny Shu, Michael J. James, Courtney Lynn Hegner, Henry D. Dionne, Alexander Rodriguez‐Palacios, Henry M. Krause, George A. O’Toole, Saul J. Karpen, Paul A. Dawson, , Mark S. Sundrud

The paper quantifies ileal bile acid pools in mice and shows that Asbt-mediated transport dominates their size and composition, with loss of Asbt reducing pool size and altering transcriptional responses.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2024Peer-reviewedPhysiology