Author

Hiroki Shima

Tohoku UniversityORCID 0000-0001-8681-8337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Kazuhiko IgarashiiD· 3 shared Akihiko MutoiD· 2 shared Daisuke SaigusaiD· 2 shared Hironari NishizawaiD· 2 shared Bert K. K. CallensiD· 1 shared Hirotaka Takekawa· 1 shared Jingyao Pang· 1 shared K MITSUYAMAiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

Kazuhiko IgarashiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 24, 2025

The nuclear role of methionine adenosyltransferase 2A in immunoglobulin class switch recombination

Yasuka Ikura, Hiroki Shima, Kanji Furuya…·Kazuhiko Igarashi

This study shows that nuclear MAT2A activity is essential for antibody class switch recombination by maintaining AID expression after germline transcription.

DOI 10.1101/2025.10.24.684368

mousebulk RNA-seq

𝕏 PostBluesky

BiochemistryGastro Hep AdvancesPeer-reviewedSep 24, 2025

Cysteine restriction induces ferroptosis depending on the polyamine biosynthetic pathway in hepatic cancer cells

Keisuke Tada, K MITSUYAMA, Hironari Nishizawa…·Kazuhiko Igarashi

This study shows that cysteine restriction induces ferroptosis in hepatic cancer cells via the polyamine biosynthetic pathway, but not in normal hepatocytes.

4 citations

mousebulk RNA-seq

𝕏 PostBluesky

BiochemistryInternational Journal of Molecular SciencesPeer-reviewedApr 9, 2024

TANK binding kinase 1 promotes BACH1 degradation through both phosphorylation-dependent and -independent mechanisms without relying on heme and FBXO22

Liang Liu, Mitsuyo Matsumoto, Miki Watanabe‐Matsui…·Kazuhiko Igarashi

7 citations

humanprotein sequence

𝕏 PostBluesky